Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides

作者:Cant Alastair A; Bhalla Rajiv; Pimlott Sally L; Sutherland Andrew*
来源:Chemical communications, 2012, 48(33): 3993-3995.
DOI:10.1039/c2cc30956d

摘要

A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer%26apos;s disease and iniparib, a compound used in the treatment of breast cancer.

  • 出版日期2012