Alveolar macrophage activation in obese patients with obstructive sleep apnea

作者：Sharma Sunil; Malur Anagha; Marshall Irene; Huizar Isham; Barna Barbara P; Pories Walter; Dohm Lynis; Kavuru Mani S; Thomassen Mary Jane^*

来源：Surgery, 2012, 151(1): 107-112.

DOI：10.1016/j.surg.2011.06.035

Background. Classically, activated macrophages in adipose tissue, live?; and muscle have been implicated in many conditions associated with obesity, including insulin resistance and the metabolic syndrome. Despite numerous pulmonary comorbidities and the sentinel role alveolar macrophages play in innate immunity and lung homeostasis, their activation status has not been examined in these patients. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been, shown to be a negative regulator of inflammation in addition to regulating lipid and glucose metabolism. PPAR-gamma is expressed constitutively in healthy alveolar macrophages and decreased on activation. We hypothesized that PPAR-gamma would be downregulated in alveolar macrophages from obese patients with obstructive sleep apnea (OSA) in the absence of overt lung disease. %26lt;br%26gt;Methods. Alveolar macrophages were obtained by bronchoalveolar lavage from obese individuals with and without OSA and healthy controls. %26lt;br%26gt;Results. Data indicated that PPAR-gamma, functional activity was decreased by 48% in obese with OSA and 26% wit/tout OSA (P %26lt; .05). In obese patients with OSA, PPAR-gamma mRNA was decreased 2-fold compared with controls (P %26lt; .05), whereas obese patients without OSA, it was not different. Regardless of OSA, alveolar macrophages of obese patients demonstrated increased interleukin-6 mRNA. %26lt;br%26gt;Conclusion. These findings are consistent with the presence of classic macrophage activation and an inflammatory lung environment. Data from this study suggest that alveolar macrophage dysfunction becomes aggravated in OSA and may increase pulmonary disease susceptibility. (Surge?), 2012;151 :107-12.)

• 出版日期2012-1