A Fast and Activatable Cross-Linking Strategy for Hydrogel Formation

作者:Jonker Anika M; Borrmann Annika; van Eck Ernst R H; van Delft Floris L; Lowik Dennis W P M; van Hest Jan C M
来源:Advanced Materials, 2015, 27(7): 1235-1240.
DOI:10.1002/adma.201404448

摘要

Strain-promoted oxidation-controlled cyclooctyne-1,2-quinone cycloaddition (SPOCQ) is a fast and activatable cross-linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ-formed hydrogels can be functionalized in one-pot with an azido-containing moiety using SPAAC cross-linking.

  • 出版日期2015-2-18

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