A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics

作者：Van Damme Ellen; Laukens Kris; Dang Thanh Hai; Van Ostade Xaveer^*

来源：International Journal of Biological Sciences, 2010, 6(1): 51-67.

• PML-NB
• SUMOylation
• Cytoscape
• protein-protein interaction
• network

Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling 'the PML-ome', we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot.

• 出版日期2010