Novel synthetic approach to fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones

作者：Ma, Yongmin^*; Hider, Robert C.

来源：Journal of Fluorine Chemistry, 2015, 173: 29-34.

DOI：10.1016/j.jfluchem.2015.02.005

• 3-Hydroxypyridin-4-one
• Iron chelator
• Fluoropyridine
• Metalation
• Carboxylation
• Protection

Starting from fluoropyridines as a building block, with chelating functional groups being introduced, several fluoro- and amido-disubstituted 3-hydroxypyridin-4-ones have been synthesized with the intention of improving the pharmaceutical profile of 3-hydroxypyridin-4-ones.

• 出版日期2015-5
• 单位浙江中医药大学