Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors

作者：Lucas Matthew C^*; Carter David S; Cai Hai Ying; Lee Eun Kyung; Schoenfeld Ryan C; Steiner Sandra; Villa Marzia; Weikert Robert J; Iyer Pravin S

来源：Bioorganic & Medicinal Chemistry Letters, 2009, 19(16): 4630-4633.

DOI：10.1016/j.bmcl.2009.06.076

• TRI
• Triple reuptake inhibitor
• Monoamine reuptake inhibitor
• Neurotransmitter
• Indole
• Major depressive disorder

A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified.

• 出版日期2009-8-15