Association of cytosine-adenine repeat polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis symptoms

作者：Gonzalez Canga A; Ugai K; Suzuki M; Okuzawa H; Negishi E; Ueno K^*

来源：Rheumatology International, 2010, 30(9): 1259-1262.

DOI：10.1007/s00296-010-1423-4

• Estrogen receptor-beta
• Gene polymorphism
• CA repeat
• Rheumatoid arthritis

The influence of the polymorphism of the estrogen receptor-beta gene, cytosine-adenine (CA) dinucleotide repeat in intron 6, in the occurrence of rheumatoid arthritis (RA) was investigated. Forty-seven RA patients and 36 control subjects with osteoarthritis (OA) were recruited. CA repeat polymorphism was examined using denaturing high-performance liquid chromatography (WAVE(A (R)) DNA Fragment Analysis System). The mean number of CA repeats was significantly higher in RA than in OA patients. Two groups were established: a parts per thousand currency sign21 repeats (short S), a parts per thousand yen22 repeats (long L); and 3 kinds of genotypes (SS, SL, LL) were found. In RA patients, the L allele frequency was higher (OR = 2.03; P a parts per thousand currency sign 0.05 Fisher's test) and more subjects carried the LL genotype (OR = 5.50; P a parts per thousand currency sign 0.05 Fisher's test) compared to OA patients. It was concluded that the presence of the L allele could be a risk factor for RA, although additional larger scale study is needed.

• 出版日期2010-7