Diabetes-Invoked High-Density Lipoprotein and Its Association With Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus

作者：Sun, Jia Teng; Liu, Yan; Lu, Lin; Liu, Hong Juan; Shen, Wei Feng; Yang, Ke^*; Zhang, Rui Yan^*

来源：American Journal of Cardiology, 2016, 118(11): 1674-1679.

DOI：10.1016/j.amjcard.2016.08.044

• C-REACTIVE PROTEIN
• ANTIINFLAMMATORY PROPERTIES
• NONENZYMATIC GLYCATION
• GLYCEMIC CONTROL
• HDL
• INFLAMMATION
• IMPAIRS

Although high-density lipoprotein (HDL) can exhibit anti-inflammatory properties, these potent activities can become deficient and even transform into proinflammatory effects under various pathophysiological states. We investigated the effect of diabetic HDL on the inflammatory response in human monocytes and its relation to the existence of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (DM). HDL was isolated from DM patients with (n = 61) or without (n = 31) CAD (diameter stenosis 50%) and healthy controls (n = 40). Human peripheral blood mononuclear cells were incubated with HDL and the proinflammatory ability of HDL was determined by tumor necrosis factor-alpha (TNF-alpha) secretion in peripheral blood mononuclear cells. Secretion of TNF-alpha in human monocytes in response to diabetic HDL was significantly increased compared with that of the control HDL. Of note, HDL from DM patients with CAD stimulated the release of TNF-alpha in monocytes to a greater extent than that of HDL from those without CAD. Multiple linear regression analysis showed that the proinflammatory ability of HDL was independently associated with diabetes duration, hemoglobin A1c, serum levels of high-sensitivity C-reactive protein (hs-CRP) and reduced glomerular filtration rate (GFR). Furthermore, the proinflammatory ability of HDL was a significant predictor for the presence of CAD in patients with DM.

• 出版日期2016-12-1
• 单位上海交通大学; 上海市闵行区中心医院