Mechanical behavior and cytocompatibility of calcium alginateor PVA/DCPP scaffolds

作者：Hu, Yang; Liang, Xue-Ping; Liu, Jing; Zhang, Lei; Shen, Yu-Feng; Yilixati, Hasim; He, Hui-Yu^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(11): 15400-15407.

• Calcium alginate
• polyvinyl alcohol
• DCCP
• tooth germ cells

Objective: The present study aimed to evaluate the mechanical performance of calcium alginate or PVA/DCPP scaffolds and their compatibility with the tooth germ cells in jaw bone defect repair. Methods: We prepared a Calcium alginate or PVA (polyvinyl alcohol)/DCPP scaffolds and observed, the ability of resistance to dissolution, setting time and mechanical property. Tooth germ cells from Sprague Dawley (SD) rats were cultured and then cocultured with two types of scaffolds, respectively. Result: In the test for resistance to dissolution, 3%, 4%, 5% and 7% calcium alginate/DCPP scaffolds and 15%, 20% and 25% PVA/DCCP scaffolds did not show obvious deformation. The calcium alginate/DCPP scaffolds had shorter setting time. PVA/DCCP scaffolds had higher shear strength which was proportional to the concentration of PVA. By scanning of electron microscopy, two scaffolds presented with inner and surface morphology similar to porous volcanic rock. The calcium alginate/DCCP scaffolds exhibited better compatibility with tooth germ cells from SD rats. Conclusion: Calcium alginate/DCCP scaffolds can be used for tissue-engineered bone repair or tissue-engineered denture repair after improvement of mechanical performance.

• 出版日期2017
• 单位新疆医科大学