Acute exercise and periodized training in different environments affect histone deacetylase activity and interleukin-10 levels in peripheral blood of patients with type 2 diabetes

作者：Korb Arthiese; Bertoldi Karine; Lovatel Gisele Agustini; Delevatti Rodrigo Sudatti; Elsner Viviane Rostirola; Ferreira Meireles Louisiana Carolina; Martins Kruel Luiz Fernando; Siqueira Ionara Rodrigues^*

来源：Diabetes Research and Clinical Practice, 2018, 141: 132-139.

DOI：10.1016/j.diabres.2018.04.037

• Type 2 diabetes
• Aerobic training
• Aquatic environment
• Land environment
• Histone deacetylase
• Cytokines

Aims: Our purpose was to investigate the effects of aerobic periodized training in aquatic and land environments on plasma histone deacetylase (HDAC) activity and cytokines levels in peripheral blood of diabetes mellitus type 2 (T2DM) patients.
Methods: The patients underwent 12 weeks of periodized training programs that including walking or running in a swimming pool (aquatic group) or in a track (dry land group). Blood samples were collected immediately before and after both first and last sessions. Plasma cytokine levels and HDAC activity in peripheral blood mononuclear cell (PBMC) was measured.
Results: The exercise performed in both environments similarly modulated the evaluated acetylation mark, global HDAC activity. However, a differential profile depending on the evaluated time point was detected, since exercise increased acutely HDAC activity in sedentary and after 12 weeks of training period, while a reduced HDAC activity was observed following periodized training (samples collected before the last session). Additionally, the 12 weeks of periodized exercise in both environments increased IL-10 levels.
Conclusions: Our data support the hypothesis that the modulation of HDAC activity and inflammatory status might be at least partially related to exercise effects on T2DM. The periodized training performed in both aquatic and land environments impacts similarly epigenetic and inflammatory status.

• 出版日期2018-7