Differentiation of malignant from benign soft tissue tumours: use of additive qualitative and quantitative diffusion-weighted MR imaging to standard MR imaging at 3.0 T

作者：Lee So Yeon; Jee Won Hee^*; Jung Joon Yong; Park Michael Y; Kim Sun Ki; Jung Chan Kwon; Chung Yang Guk

来源：European Radiology, 2016, 26(3): 743-754.

DOI：10.1007/s00330-015-3878-x

• MRI
• Diffusion magnetic resonance imaging
• Sarcoma
• Soft tissue neoplasms
• Differential diagnosis

To determine the added value of diffusion-weighted imaging (DWI) to standard magnetic resonance imaging (MRI) to differentiate malignant from benign soft tissue tumours at 3.0 T.
3.0 T MR images including DWI in 63 patients who underwent surgery for soft tissue tumours were retrospectively analyzed. Two readers independently interpreted MRI for the presence of malignancy in two steps: standard MRI alone, standard MRI and DWI with qualitative and quantitative analysis combined.
There were 34 malignant and 29 non-malignant soft tissue tumours. In qualitative analysis, hyperintensity relative to skeletal muscle was more frequent in malignant than benign tumours on DWI (P=0.003). In quantitative analysis, ADCs of malignant tumours were significantly lower than those of non-malignant tumours (Pa parts per thousand currency sign0.002): 759 +/- 385 vs. 1188 +/- 423 mu m(2)/sec minimum ADC value, 941 +/- 440 vs. 1310 +/- 440 mu m(2)/sec average ADC value. The mean sensitivity, specificity and accuracy of both readers were 96 %, 72 %, and 85 % on standard MRI alone and 97 %, 90 %, and 94 % on standard MRI with DWI.
The addition of DWI to standard MRI improves the diagnostic accuracy for differentiation of malignant from benign soft tissue tumours at 3.0 T.
aEuro cent DWI has added value for differentiating malignant from benign soft tissue tumours.
aEuro cent Addition of DWI to standard MRI at 3.0 T improves the diagnostic accuracy.
aEuro cent Measurements of both ADC (min) within solid portion and ADC (av) are helpful.

• 出版日期2016-3