Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice

作者：Fiorucci Stefano^*; Mencarelli Andrea; Cipriani Sabrina; Renga Barbara; Palladino Giuseppe; Santucci Luca; Distrutti Eleonora

来源：British Journal of Pharmacology, 2011, 164(8): 1929-1938.

DOI：10.1111/j.1476-5381.2011.01481.x

• Acetyl salicylic acid
• bile acids
• cystathionine-?- lyase
• farnesoid X receptor
• hydrogen sulphide
• nitric oxide
• non-steroidal anti-inflammatory drugs
• nuclear receptors

BACKGROUND AND PURPOSE Low doses of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage. The farnesoid X receptor (FXR) is a bile acid sensor essential for maintenance of intestinal homeostasis. Here, we have investigated whether FXR is required for mucosal protection in models of gastrointestinal injury caused by ASA and NSAIDs and if FXR activation has potential in the treatment or prevention of gastrointestinal injury caused by these agents.

• 出版日期2011-12