Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats

作者：Talwar Sahil; Nandakumar K^*; Nayak Pawan G; Bansal Punit; Mudgal Jayesh; Mor Vijay; Rao Chamallamudi Mallikarjuna; Lobo Richard

来源：Journal of Ethnopharmacology, 2011, 134(2): 323-328.

DOI：10.1016/j.jep.2010.12.015

• Terminalia paniculata
• Carrageenan-induced rat paw edema
• Carrageenan-induced air pouch inflammation
• Complete Freund's adjuvant-induced arthritis
• Anti-inflammation
• Anti-rheumatism

Ethnopharmacological relevance: Terminalia paniculata Roxb. (Family-Combretaceae) is a wild tree commonly used in traditional ayurvedic medicine for the treatment of inflammation of parotid glands and in menstrual disorders.
Aim of the study: To explore the folk use of Terminalia paniculata on pharmacological grounds to evaluate the scientific basis of anti-inflammatory activity.
Materials and methods: The anti-inflammatory activity of Terminalia paniculata was studied against carrageenan-induced hind paw edema, air pouch inflammation and complete Freund's adjuvant (CFA)-induced arthritis in rats. The aqueous extract of Terminalia paniculata bark (TPW) was administered at the concentrations of 100, 200 and 400 mg/kg body weight.
Results: TPW showed significant (p < 0.05) anti-inflammatory activity by reducing the edema volume in carrageenan-induced paw edema in rats. Further, TPW (400 mg/kg) also reduced the carrageenan-induced leukocyte migration (50.92 +/- 5.71%) and myeloperoxidase activity (49.31 +/- 5.24%) in air pouch exudates. TPW (200 mg/kg) exhibits anti-rheumatic and analgesic activities by improving the altered haematological milieu (ESR, CRP, RF, WBC, RBC and Hb) and also by inhibiting the flexion scores and radiographic changes in CFA-induced arthritis. This extract also had significant (p < 0.05) effects on the occurrence of secondary lesions compared to CFA control.
Conclusions: Terminalia paniculata bark may be a potential preventive or therapeutic candidate for the treatment of chronic inflammation and arthritis.

• 出版日期2011-3-24