Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer%26apos;s Disease: an Emerging Issue in Geriatric NeuroHIV

作者：Milanini Benedetta; Valcour Victor

来源：Current HIV/AIDS Reports, 2017, 14(4): 123-132.

DOI：10.1007/s11904-017-0361-0

• HIV
• HAND
• Alzheimer's disease
• Cognitive impairment
• Biomarkers
• Neurodegeneration

Purpose of Review The purpose of this review was to examine characteristics that may distinguish HIV-associated neurocognitive disorder (HAND) from early Alzheimer's disease (AD).
Recent Findings Cerebrospinal fluid (CSF) AD biomarkers are perturbed in HIV, yet these alterations may be limited to settings of advanced dementia or unsuppressed plasma HIV RNA. Neuropsychological testing will require extensive batteries to maximize utility. Structural imaging is limited for early AD detection in the setting of HIV, but proper studies are absent. While positron-emission tomography (PET) amyloid imaging has altered the landscape of differential diagnosis for age-associated neurodegenerative disorders, costs are prohibitive.
Summary Risk for delayed AD diagnosis in the aging HIVinfected population is now among the most pressing issues in geriatric neuroHIV. While clinical, imaging, and biomarker characterizations of AD are extensively defined, fewer data define characteristics of HIV-associated neurocognitive disorder in the setting of suppressed plasma HIV RNA. Data needed to inform the phenotype of AD in the setting of HIV are equally few.

• 出版日期2017-8