科研之友
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摘要
Many proteins associated with neurodegenerative diseases have poorly defined or unknown functions. alpha-Synuclein is one such protein which is associated with a range of diseases including Parkinson%26apos;s disease. Now accepted as a metal-binding protein, alpha-synuclein%26apos;s function could possibly be defined in relation to the binding of cofactors. It has been suggested recently that alpha-synuclein is able to reduce iron using copper as its catalytic centre. The consequence of this is that possibly the function of alpha-synuclein can now be defined. The evidence for this and the consequences for Parkinson%26apos;s disease are discussed in the present review.
- 出版日期2013-12
