Acute promyelocytic leukaemia with a novel translocation t(16;17) (q12;p13): a case report

作者：Bhat Hilal; Geelani Sajad; Rashid Masrat; Bhat Tariq; Qadri Mudasir; Bashir Nusrat^*; Manzoor Fahim; Bhat Shuaeb; Rather Fayaaz; Rasool Javid

来源：Malaysian Journal of Pathology, 2016, 38(3): 311-313.

• Novel translocation
• acute promyelocytic leukaemia
• fusion genes

Acute promyelocytic leukaemia (APML) is characterised by the t(15; 17)(q22; q21), that results in the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16; 17). To the best of our knowledge this is the first case report of APML responsive to ATRA with such a translocation.

• 出版日期2016-12
• 单位河北医科大学