Molecular Phylogeny of Edge Hill Virus Supports its Position in the Yellow Fever Virus Group and Identifies a New Genetic Variant

作者：Macdonald Joanne; Poidinger Michael; Mackenzie John S; Russell Richard C; Doggett Stephen; Broom Annette K; Phillips Debra; Potamski Joseph; Gard Geoff; Whelan Peter; Weir Richard; Young Paul R; Gendle Debra; Maher Sheryl; Barnard Ross T; Hall Roy A^*

来源：Evolutionary Bioinformatics, 2010, 6: 91-96.

• Edge Hill virus
• EHV
• yellow fever virus
• flavivirus

Edge Hill virus (EHV) is a mosquito-borne flavivirus isolated throughout Australia during mosquito surveillance programs. While not posing an immediate threat to the human population, EHV is a taxonomically interesting flavivirus since it remains the only member of the yellow fever virus (YFV) sub-group to be detected within Australia. Here we present both an antigenic and genetic investigation of collected isolates, and confirm taxonomic classification of the virus within the YFV-group. Isolates were not clustered based on geographical origin or time of isolation, suggesting that minimal genetic evolution of EHV has occurred over geographic distance or time within the EHV cluster. However, two isolates showed significant differences in antigenic reactivity patterns, and had a much larger divergence from the EHV prototype (19% nucleotide and 6% amino acid divergence), indicating a distinct subtype or variant within the EHV subgroup.

• 出版日期2010