Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

作者：Pereira Marcos D P; Ferreira Matheus R; Messiano Gisele B; Ceravolo Isabela Penna; Lopes Lucia M X^*; Krettli Antoniana U

来源：Phytochemistry Letters, 2015, 13: 200-205.

DOI：10.1016/j.phytol.2015.06.001

• Holostylis reniformis
• Aristolochiaceae
• Lignans
• Aryltetralol
• Arytetralene
• Antiplasmodial activity

Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (-)-8'-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods. Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL50) evaluated. (-)-Cyclogalgravin and (-)-aristoligol exhibited activity (IC50 similar to 10.8 and 8.4 mu M, respectively), the latter exhibited lower toxicity.

• 出版日期2015-9