A smartphone based surface plasmon resonance imaging (SPRi) platform for on-site biodetection

作者：Guner Hasan; Ozgur Erol; Kokturk Guzin; Celik Mehmet; Esen Elif; Topal Ahmet E; Ayas Sencer; Uludag Yildiz; Elbuken Caglar; Dana Aykutlu^*

来源：Sensors and Actuators B: Chemical , 2017, 239: 571-577.

DOI：10.1016/j.snb.2016.08.061

• Plasmonics
• Surface plasmon resonance imaging
• Optical discs
• Mobile sensing
• Biosensors
• Optical sensor

We demonstrate a surface plasmon resonance imaging platform integrated with a smartphone to be used in the field with high-throughput biodetection. Inexpensive and disposable SPR substrates are produced by metal coating of commercial Blu-ray discs. A compact imaging apparatus is fabricated using a 3D printer which allows taking SPR measurements from more than 20.000 individual pixels. Real-time bulk refractive index change measurements yield noise equivalent refractive index changes as low as 4.12 x 10(-5) RIU which is comparable with the detection performance of commercial instruments. As a demonstration of a biological assay, we have shown capture of mouse IgG antibodies by immobilized layer of rabbit anti-mouse (RAM) IgG antibody with nanomolar level limit of detection. Our approach in miniaturization of SPR biosensing in a cost-effective manner could enable realization of portable SPR measurement systems and kits for point-of-care applications.

• 出版日期2017-2