A facile synthesis of norathyriol

作者:Qin, Qi-xue; Yang, Jian*; Yang, Bo; Liu, Man; Xiao, Dan; Yang, Xuemin
来源:Journal of Chemical Research, 2013, 37(1): 38-39.
DOI:10.3184/174751912X13547158602399

摘要

In this paper, norathyriol has been synthesised from 2-bromo-4,5-dimethoxybenzoic acid and 1,3,5-trimethoxybenzene by a three-step sequence of transformations involving a Friedel-Crafts acylation with cyclisation and demethylation. The procedure was facile and should be easily scaled-up. The overall yields reached approximately 70%.

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