Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography

作者：Kim Hye Geum; Kong Eun Jung; Cheon Eun Jin; Kim Hae Won; Koo Bon Hoon

来源：Clinical Psychopharmacology and Neuroscience, 2016, 14(4): 378-382.

DOI：10.9758/cpn.2016.14.4.378

• Amyloid positron emission tomography
• Geriatric depression
• Alzheimer disease
• Subjective memory complaint

The purpose of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using F-18-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region. The amyloid deposition of the whole brain region was significantly negatively correlated with immediate memory.

• 出版日期2016-11