ERP C250 shows the elderly (cognitively normal, Alzheimer's disease) store more stimuli in short-term memory than Young Adults do

作者：Chapman Robert M^*; Gardner Margaret N; Mapstone Mark; Klorman Rafael; Porsteinsson Anton P; Dupree Haley M; Antonsdottir Inga M; Kamalyan Lily

来源：Clinical Neurophysiology, 2016, 127(6): 2423-2435.

DOI：10.1016/j.clinph.2016.03.006

• Event-Related Potentials (ERP)
• Electrophysiology
• Alzheimer's disease (AD)
• Short-term memory
• Principal Components Analysis (PCA)
• Short-latency ERP component C250

Objective: To determine how aging and dementia affect the brain's initial storing of task-relevant and irrelevant information in short-term memory.
Methods: We used brain Event-Related Potentials (ERPs) to measure short-term memory storage (ERP component C250) in 36 Young Adults, 36 Normal Elderly, and 36 early-stage AD subjects. Participants performed the Number-Letter task, a cognitive paradigm requiring memory storage of a first relevant stimulus to compare it with a second stimulus.
Results: In Young Adults, C250 was more positive for the first task-relevant stimulus compared to all other stimuli. C250 in Normal Elderly and AD subjects was roughly the same to relevant and irrelevant stimuli in Intratrial Parts 1-3 but not 4. The AD group had lower C250 to relevant stimuli in part 1.
Conclusions: Both normal aging and dementia cause less differentiation of relevant from irrelevant information in initial storage. There was a large aging effect involving differences in the pattern of C250 responses of the Young Adult versus the Normal Elderly/AD groups. Also, a potential dementia effect was obtained.
Significance: C250 is a candidate tool for measuring short-term memory performance on a biological level, as well as a potential marker for memory changes due to normal aging and dementia.

• 出版日期2016-6