ANTIPSYCHOTIC TREATMENT EMERGENT ADVERSE EVENTS IN CORRELATION WITH THE PHARMACOGENETIC TESTING AND DRUG INTERACTIONS IN CHILDREN AND ADOLESCENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER

作者：Andreescu Nicoleta; Nus**aum Laura^*; Hogea Lavinia Maria; Gradinaru Raluca; Muntean Calin; Stefanescu Radu; Puiu Maria

来源：Farmacia, 2016, 64(5): 736-744.

• antipsychotics
• pharmacogenetic
• CYP2D6
• adverse events
• aripiprazole
• risperidone

Even though a shift toward the use of second generation of modem atypical antipsychotics was partly justified by their lower risk of extrapyramidal symptoms, their serious adverse effects include high risk of weight gain, hyperinsulinemia, metabolic syndrome, type 2 diabetes mellitus. Especially in children and adolescents, the choice of antipsychotic medication should be driven by the safety and side effects profiles. The present study is part of an extensive research on pharmacological treatment in child and adolescent psychoses, performed between 2007 and 2015, focused especially on safety aspects, treatment emergent adverse events (TEAE) and pharmacogenetic correlations. The study group consisted of 90 patients, children and adolescents with psychosis (schizophrenia and bipolar disorder). The primary objective of our study was to evaluate the safety and the adverse events of aripiprazole compared with risperidone in the studied paediatric population. Also a major objective was to establish some correlations between the pharmacogenetic profile of the subjects and the presence of treatment emergent adverse events. We investigated also variables like BMI (Body Mass Index), blood insulin increase in different time points after the long duration administration of the antipsychotic treatment. The obtained results proved a high safety profile, especially for aripiprazole and high correlations of the emergence of the adverse events with the pharmacogenetic profile of the subjects.

• 出版日期2016-10