The role of vitamin D in paediatric bone health

作者：Pettifor John M^*; Prentice Ann

来源：Best Practice & Research Clinical Endocrinology & Metabolism, 2011, 25(4): 573-584.

DOI：10.1016/j.beem.2011.06.010

• vitamin D deficiency
• rickets
• ultraviolet radiation
• skeletal health
• bone mass
• foetal growth
• bone growth

Recently there has been renewed interest in the role of vitamin D in paediatric bone health. Its role in the development of rickets and hypocalcaemia in infants and young children, in particular, in many part of the world is well known, and the importance of the prevention of vitamin D deficiency during pregnancy and lactation has been highlighted. Less clear are the possible effects that maintaining maternal vitamin D sufficiency might have on foetal and early infant growth and bone development. There is little evidence to suggest that maintaining childhood vitamin D status well above that necessary to prevent rickets has an effect on intestinal calcium absorption or on peak bone mass. Further studies are needed in these areas prior to definitive conclusions are drawn about the optimal vitamin D requirements and circulating 25(OH)D concentrations for foetal, infant and childhood bone health.

• 出版日期2011-8