Associations of plasma homocysteine levels with peripheral systolic blood pressure and noninvasive central systolic blood pressure in a communitybased Chinese population

作者：Momin, Mohetaboer; Fan, Fangfang; Li, Jianping; Qin, Xianhui; Jia, Jia; Qi, Litong; Zhang, Yan^*; Huo, Yong^*

来源：Scientific Reports, 2017, 7(1): 6316.

DOI：10.1038/s41598-017-06611-3

• INSULIN-RESISTANCE
• ESSENTIAL-HYPERTENSION
• ARTERIAL STIFFNESS
• CONTROLLED TRIAL
• RISK
• ACID
• PULSE
• CHILDREN
• INDEXES
• HEALTH

Previous studies indicated that homocysteine (Hcy) is associated with higher peripheral systolic blood pressure (pSBP). There have been few data on the relationship between Hcy and central SBP (cSBP). A total of 4,364 Chinese subjects from the Shijingshan community in Beijing were included. cSBP and pSBP were measured with an Omron HEM-9000AI device. Subjects were 57.20 +/- 8.9 years old, 37.9% were male. The median of Hcy was 11.96 mu mol/L. The mean of cSBP and pSBP was 129.94 +/- 18.03 mmHg and 133.25 +/- 18.58 mmHg. lnHcy was associated with cSBP (adjusted beta = 2.17, SE = 0.80, P = 0.007) and pSBP (adjusted beta = 2.42, SE = 0.75, P = 0.001). With increasing Hcy, there were enhanced correlations of Hcy with pSBP and cSBP (p for trend between quartiles < 0.01). Using Q1 for reference, the Q4 was associated with cSBP (adjusted beta = 1.77, SE = 0.89, P = 0.047) and pSBP (adjusted beta = 2.15, SE = 0.84, P = 0.011). The correlations were more significant in non-obese subjects than in obese subjects (cSBP: beta = 4.30 vs 0.46, pSBP: beta = 5.04 vs 1.18, P for interaction < 0.001). Our study showed that Hcy was associated with higher cSBP and pSBP, especially in non-obese subjects.

• 出版日期2017-7-24
• 单位南方医科大学; 北京大学