Antioxidant and free radical-scavenging activity of the extracellular death factor in Escherichia coli

作者：Gao Yanfeng^*; Chen Kun; Zhang Bin; Li Xiang; Chen Lu; Li Yuanjun; Jia Xiangjiao; Lei Yongxing; Yan Zhongyi; Kong Liangliang; Wang Nan; Liu Wei; Qi Yuanming

来源：Peptides, 2010, 31(10): 1821-1825.

DOI：10.1016/j.peptides.2010.06.034

• Extracellular death factor
• Free radical
• Antioxidant
• Programmed cell death
• Quorum-sensing

The extracellular death factor (EDF) is a newly discovered linear pentapeptide with the sequence of H-Asn-Asn-Trp-Asn-Asn-OH (NNWNN). It could act as a quorum-sensing molecule and participate in the mazEF-mediated cell death in Escherichia coli. In the present study, we firstly studied the antioxidant and free radical-scavenging activities of EDF. EDF could scavenge hydroxyl radicals in vitro and protect protein, lipid and DNA from being damaged by hydroxyl radicals. Our results indicated that this extracellular death factor might have dual effects during the programmed cell death process of Escherichia coli.

• 出版日期2010-10
• 单位郑州大学