Antineoplastic agents. 558. Ampelocissus sp cancer cell growth inhibitory constituents

作者:Pettit George R*; Mukku Venugopal J R V; Cragg Gordon; Herald Delbert L; Knight John C; Herald Cherry L; Chapuis Jean Charles
来源:Journal of Natural Products, 2008, 71(1): 130-133.
DOI:10.1021/np068050q

摘要

An investigation of the Phillippine Ampelocissus sp. roots for cancer cell growth inhibitory components led to the isolation of a new acetogenin characterized as 22-epicalamistrin (1) employing primarily 2D NMR and high-resolution mass spectral analysis. Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines.

  • 出版日期2008-1