Azacytidine in combination with tyrosine kinase inhibitors induced durable responses in patients with advanced phase chronic myelogenous leukemia

作者：Ruggiu Mathilde; Oberkampf Florence; Ghez David; Cony-Makhoul Pascale; Beckeriche Florence; Cano Isabelle; Taksin Anne L.; Benbrahim Omar; Ghez Stephanie; Farhat Hassan; Rigaudeau Sophie; de Gunzburg Noemie; Lara Diane; Terre Christine; Raggueneau Victoria; Garcia Isabel; Spentchian Marc; De Botton Stephane; Rousselot Philippe^*

来源：Leukemia and Lymphoma, 2018, 59(7): 1659-1665.

DOI：10.1080/10428194.2017.1397666

• Advanced phase CML
• azacytidine
• tyrosine kinase inhibitors

Although the tyrosine kinase inhibitor (TKI) era has brought great improvement in outcome in chronic myelogenous leukemia (CML), prognosis of accelerated phase or myeloid blast crisis patients or of de novo Philadelphia chromosome-positive acute myeloid leukemia remains poor. We conducted a retrospective study on patients with advanced phase disease treated with a TKI and azacytidine. Sixteen patients were eligible. Median age was 64.9 years, the median number of previous therapies was 2.5 lines, and median follow-up was 23.1 months. Hematologic response (HR) rate was 81.3%. Median overall survival (OS), event free survival and relapse-free survival (RFS) were 31.5, 23.3, and 32.2 months, respectively. All except one patient were treated as out-patients after the first cycle. Five patients were bridged to allogenic hematopoietic stem cells transplant. The combination of a TKI and azacytidine is a safe and efficient regiment for patients with CML patients in advanced phases.

• 出版日期2018