Anti-Mycobacterium avium complex activity of clarithromycin, rifampin, rifabutin, and ethambutol in combination with adenosine 5 %26apos;-triphosphate

作者：Tatano Yutaka; Yamabe Seiko; Sano Chiaki; Tomioka Haruaki

来源：Diagnostic Microbiology and Infectious Disease, 2017, 88(3): 241-246.

DOI：10.1016/j.diagmicrobio.2017.04.012

• ATP
• Antimycobacterial drugs
• Combined effects
• Mycobacterium avium complex

We previously reported that adenosine 5 '-triphosphate (ATP) inhibited the growth of various bacteria, including mycobacteria, Staphylococcus, and Pseudomonas, without damaging bacterial surface structures. Notably, ATP's antibacterial activity was found to be attributable to its iron-chelating ability. ATP exhibited combined effects with some antimicrobials against Mycobacterium intracellulare and methicillin-resistant S. aureus, suggesting its usefulness as an adjunctive drug in the chemotherapy against certain intractable infections. In this study, we examined detailed profiles of the anti-Mycobacterium avium complex (MAC) activity of some antimicrobial agents, including clarithromycin (CIA), rifampin (RIF), rifabutin (RBT), and ethambutol (EMB), in combination with ATP. It was found that the anti-MAC activity of CLA + RIF, CIA + RBT, and CIA + EMB was markedly potentiated in a strain-dependent manner. In this case, the onset of the regrowth of antimicrobial agent-treated mycobacteria during cultivation was significantly delayed in the presence of ATP, indicating the usefulness of ATP as an adjunctive drug in chemotherapy against MAC infections.

• 出版日期2017-7