Phytochemical Studies and Antioxidant Activities of Artocarpus scortechinii King

作者：Arriffin Norzafneza Mohd; Jamil Shajarahtunnur^*; Basar Norazah; Khamis Shamsul; Abdullah Siti Awanis; Lathiff Siti Mariam Abdul

来源：Records of Natural Products, 2017, 11(3): 299-303.

• Artocarpus scortechinii
• isolation
• antioxidant
• DPPH
• ABTS
• FRAP

Six known compounds identified as 4', 5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-.gamma,gamma-dimethylallyflavone (1), cudraflavone A (2), artocarpin (3), cycloartobiloxanthone (4), artonin E (5) and oxyresveratrol (6) were isolated from the stem barks of Artocapus scortechinii King. Another four compounds namely macakurzin C (7), flemichapparin A (8), luteolin (9) and apigenin (10) were isolated from the leaves. Structures of all pure compounds were elucidated spectroscopically using 1D NMR (H-1, C-13, DEPT), 2D NMR (COSY, HMQC, HMBC), MS and FTIR, as well as by comparison with literature data. All isolated compounds were evaluated for their antioxidant capacities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) and ferric reducing antioxidant potential (FRAP) assays. Luteolin (9) showed the best ability to act as DPPH free radical scavenger with IC50 value of 9.51 mu M. Luteolin (9) also exhibited the strongest scavenger and potent ferric ion reducer compared to other isolated compounds in the ABTS and FRAP assays with IC50 value of 124.4 mu M and 4.07 +/- 0.180 mM FRAP equivalent respectively.

• 出版日期2017-6