Antiretroviral therapy partly reverses the systemic and mucosal distribution of NK cell subsets that is altered by SIVmac251 infection of macaques

作者：Liyanage Namal P M; Gordon Shari N; Doster Melvin N; Pegu Poonam; Vaccari Monica; Shukur Nebiyu; Schifanella Luca; Pise Masison Cynthia A; Lipinska Danuta; Grubczak Kamil; Moniuszko Marcin; Franchini Genoveffa^*

来源：Virology, 2014, 450: 359-368.

DOI：10.1016/j.virol.2013.12.003

• HIV
• SIV
• NK cell
• Macaques
• Innate immunity
• ART
• Mucosal
• Innate lymphoid cells
• HAART
• Chemokine receptor

We characterized three subsets of NK cells in blood, and two subsets in mucosal tissues. SIVmac251 infection increased total and CD16(+) NK cells in the blood. In the rectum, we observed a significant increase in total and NKG2A(+) NK cells during SIV infection. In contrast, the NKp44(+) subset significantly depleted in acute infection and continued to decline in frequency during chronic phase. During SIV infection, blood CD16 and mucosal NKG2A(+) subsets had increased cytotoxic potential. Intriguingly, the NKp44(+) NK cell subtype that likely mediates mucosal homeostasis via the production of cytokines, acquired cytotoxicity. Antiretroviral therapy significantly increased the frequency of mucosal NKG2A(+) NK cells and peripheral CD16(+) NK cells. However, it failed to restore the normal frequency of NKp44(+) NK cells in the rectum. Thus, SIVmac251 infection causes changes in the distribution and function of NK cells and antiretrovii-al therapy during chronic infection only partially restores NK homeostasis and function. Published by Elsevier Inc.

• 出版日期2014-2
• 单位NIH