Determination of Median Lethal Dose of Enrofloxacin Microemulsion in Mice

作者：Yang Xue Feng; Liu Dong Yang; Han Qing Gong; Sun Ya Wei; Fan Guo Ying^*

来源：Pakistan Veterinary Journal, 2015, 35(2): 155-158.

• Acute toxicity test
• Enrofloxacin
• Median lethal dose
• Mice
• Microemulsion

As a novel formulation of enrofloxacin, the toxicity of enrofloxacin microemulsion was unknown. The present study was conducted to determine the median lethal dose (LD50) of enrofloxacin microemulsion by using the acute toxicity test in mice. Based on the dose range of the pretest, mice in the group receiving the enrofloxacin microemulsion were intragastrically administered the dose levels of 1320.0, 1056.0, 844.8, 675.84, 540.67 and 432.6 mg/kg of body weight, respectively. LD50 calculated by Bliss method was 740.08 mg/kg, and 95% confidence limit of LD50 was 647.11 +/- 844.87 mg/kg, which indicated enrofloxacin microemulsion could be labeled as the hazard category 4 according to GHS and be considered as a low toxicity drug.

• 出版日期2015
• 单位河南科技学院