Acute effects of an exposure to 100 ppm 1-methoxypropanol-2 on the upper airways of human subjects

作者：Muttray A^*; Gosepath J; Brieger J; Faldum A; Mayer Popken O; Jung D; Ros**ach B; Mann W; Letzel S

来源：Toxicology Letters, 2013, 220(2): 187-192.

DOI：10.1016/j.toxlet.2013.04.014

• 1-Methoxypropanol-2
• Inhalation
• Upper airways
• Inflammation
• Olfactory threshold
• Mucociliary transport

The German MAK value of 1-methoxypropanol-2 has been fixed at 100 ppm. The aim of this study was to evaluate possible acute effects of an exposure to 100 ppm 1-methoxypropanol-2 on the upper airways of human subjects. Twenty subjects were exposed in a crossover design to 100 ppm 1-methoxypropanol-2 and to air in an exposure chamber for 4 h. Subjective symptoms were assessed by questionnaire. Olfactory thresholds for n-butanol and mucociliary transport time were measured before and after exposure. Concentrations of interleukin 1 beta and interleukin 8 were determined in nasal secretions taken after exposure. mRNA levels of interleukins 1 beta, 6 and 8, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1, and cyclooxygenases 1 and 2 were measured in nasal epithelial cells, obtained after exposure. Possible effects were investigated by semiparametric and parametric cross-over analyses. Subjects did not have any subjective irritating symptoms. The olfactory threshold was slightly elevated following exposure to 1-methoxypropanol-2. Mucociliary transport time did not change. Neither concentrations of interleukins in nasal secretions nor mRNA levels except for interleukin 1 beta were higher after exposure to 1-methoxypropanol-2.

• 出版日期2013-7-4
• 单位河北医科大学