MSQoL-54 predicts change in fatigue after inpatient rehabilitation for people with multiple sclerosis

作者：Drulovic Jelena^*; Bursac Lidija Obradovic; Milojkovic Dragana; Tepavcevic Darija Kisic; Gazibara Tatjana; Pekmezovic Tatjana

来源：Disability and Rehabilitation, 2013, 35(5): 362-366.

DOI：10.3109/09638288.2012.704122

• Fatigue
• inpatient rehabilitation
• MSQoL-54
• multiple sclerosis
• prediction
• quality of life

Purpose: The aim of our study was to investigate the impact of a short-term inpatient rehabilitation program on fatigue in patients with multiple sclerosis (MS) and to assess whether the scales of Multiple Sclerosis Quality of Life 54 (MSQoL-54) could predict change in fatigue after rehabilitation. Method: Included in the study were 151 moderately disabled MS patients admitted for 3 weeks of inpatient rehabilitation. Fatigue (Fatigue Severity Scale; FSS) was assessed at baseline and after treatment, and quality of life (MSQoL-54), disability (Expanded Disability Status Scale; EDSS) and depression (Beck Depression Inventory; BDI) were estimated at baseline. Results: Sixty-four percentage of the subjects showed fatigue. Both EDSS (r = 0.720, p = 0.001) and BDI (r = 0.655, p = 0.001) scores showed statistically significant positive correlation with FSS scores. Significant negative correlation was demonstrated between FSS and both, Physical Health Composite (PHC) and Mental Health Composite (MHC) scores of MSQoL-54 (r = -0.770, p = 0.001, and r = -0.646, p = 0.001, respectively). The mean FSS score significantly decreased by 0.19 +/- 0.29 points in the fatigue group, immediately after rehabilitation. The multiple regression analyses with change of FSS as dependent variable and baseline scores of MSQoL-54 as independent variables showed statistically significant relation between change in fatigue and baseline PHC score (p = 0.034). Conclusions: Inpatient rehabilitation decreased MS patients' fatigue. Change in fatigue was predicted with certain domains of QoLat baseline.

• 出版日期2013