Preparation of differentially substituted 3,6-diaminopyridazines under mild conditions

作者：Bethel Paul A; Roberts Bryan; Bailey Andrew^*

来源：Tetrahedron Letters, 2014, 55(37): 5186-5190.

DOI：10.1016/j.tetlet.2014.07.096

• 3,6-Diaminopyridazines
• Ullmann-type coupling
• Copper catalyst
• L-Hydroxyproline

Although desirable from a medicinal chemistry perspective, the differentially substituted 3,6-diaminopyridazine moiety is a highly challenging target using current literature approaches. Recent methods of Ullmann-type couplings are evaluated and a mild route to prepare these structures from iodide precursors is presented.

• 出版日期2014-9-10