Deciphering the Selectivity of Bombyx mori Pheromone Binding Protein for Bombykol over Bombykal: A Theoretical Approach

作者：Charlier Landry; Antonczak Serge; Jacquin Joly Emmanuelle; Cabrol Bass Daniel; Golebiowski Jerome^*

来源：ChemPhysChem, 2008, 9(18): 2785-2793.

DOI：10.1002/cphc.200800343

• free-energy relationships
• molecular dynamics
• pheromones
• selectivity
• theoretical chemistry

In this article we report calculations dedicated to estimate the selectivity of the Bombyx mori pheromone binding protein towards the two closely related pheromonal components Bombykol and Bombykol. The selectivity is quantified by the binding free-energy difference, obtained either by the thermodynamic integration or by the MM-GBSA approach. In the latter, the selectivity is decomposed on a per-residue basis, which identifies the residues considered crucial for the selectivity of the protein for Bombykol over Bombykol. A discussion on the role of Bombyx mori pheromone binding protein is provided on the basis of these results.

• 出版日期2008-12-22