科研之友
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摘要
Equol is a nonsteroidal estrogen metabolized from the soy isoflavone daidzein by intestinal bacteria. Although its clinical benefits remain unclear, many reports have demonstrated that equol plays various biological roles in cancer, osteoporosis, and cardiovascular disease. Contrary to reports in other systems, the function of equol in the olfactory system has not been well understood. In the olfactory system, various odorants can bind to their receptors on olfactory sensory neurons and subsequently activate adenylyl cyclase (AC). Increased cAMP levels via the activated AC modulate Ca2+ influx and lead to altered membrane potential. This process results in transmission of electric signals to the brain. Because cANIP signal transduction and Ca2+ levels play crucial roles in the olfactory system, we investigated the effects of equol on the cANIP pathway and Ca2+ influx after stimulation by the odorant eugenol in gastric adenocarcinoma cells. Our results reveal that the up regulated cAMP level by eugenol was significantly decreased by equol treatment. Phosphorylation of PKA and CREB, downstream targets of cAMP was also reduced. Furthermore, the odorant-induced Ca2+ levels were decreased in the presence of equol. Taken together, these data suggest that equol inhibits the odorant-induced signaling pathway through modulation of PKA/CREB signaling transduction.
- 出版日期2013-11
