Downregulation of caspase-9 is a frequent event in patients with stage II colorectal cancer and correlates with poor clinical outcome

作者：Shen X G; Wang C; Li Y; Wang L; Zhou B; Xu B; Jiang X; Zhou Z G^*; Sun X F

来源：Colorectal Disease, 2010, 12(12): 1213-1218.

DOI：10.1111/j.1463-1318.2009.02009.x

• Stage II
• colorectal cancer
• caspase-9
• apoptosis
• prognostic factor

Objective To evaluate the clinical significance of caspase-9 mRNA expression and investigate its prognostic value in stage II colorectal cancer.
Method Quantitative real-time RT-PCR was used to analyse caspase-9 mRNA expression in cancer tissue and corresponding normal mucosa from 120 patients.
Results Compared with normal mucosa, the expression of caspase-9 mRNA was found to be downregulated in cancer tissue (P = 0.001). Poorly differentiated cancer showed lower mRNA expression than cancer with greater differentiation (P = 0.031). The Kaplan-Meier survival analysis demonstrated that patients with downregulated caspase-9 showed a worse overall survival (P = 0.012) and disease-free survival (P = 0.022). Cox's proportional hazards regression model confirmed that expression of caspase-9 was the strongest prognostic factor in stage II colorectal cancer.
Conclusion The mRNA expression of caspase-9 can be used as an independent prognostic factor for patients with stage II colorectal cancer.

• 出版日期2010-12
• 单位四川大学