A Mild and Versatile Method for the Synthesis of Alkyl Ethers from Methoxymethyl Ethers and Application to the Preparation of Sterically Crowded Ethers

作者：Minamitsuji Yutaka; Kawaguchi Atsuhisa; Kubo Ozora; Ueyama Yoshifumi; Maegawa Tomohiro; Fujioka Hiromichi^*

来源：Advanced Synthesis & Catalysis, 2012, 354(10): 1861-1866.

DOI：10.1002/adsc.201200290

• alkyl ethers
• alkylation
• crowded ethers
• nucleophilic substitution
• organocuprates
• pyridinium-type salts

A mild and divergent route for the synthesis of alkyl ethers from methoxymethyl (MOM) and methoxyethyl (ME) ether derivatives via pyridinium-type salt intermediates has been developed. The addition of organocuprates to the salts afforded the corresponding alkyl ethers, including highly crowded ones, in high yields even in the presence of acid- or base-sensitive functional groups.

• 出版日期2012-7