Association of angiotensin converting enzyme gene insertion/deletion polymorphism with lung cancer in Turkey

作者：Nacak Muradiye^*; Nacak Ibrahim; Sanli Maruf; Ozkur Mehtap; Pektas Mehtap; Aynacioglu A Suekrue

来源：Cancer Genetics and Cytogenetics, 2010, 198(1): 22-26.

DOI：10.1016/j.cancergencyto.2009.11.019

Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. We investigated an insertion/deletion (I/D) polymorphism of the gene for ACE in relation to cardiovascular, cerebrovascular, neurodegenerative, and inflammatory diseases. The purpose of the present study was to investigate a possible association between lung cancer and insertion/deletion polymorphism of the ACE gene. A total of 125 patients with lung cancer and 165 control subjects were enrolled in the present study. ACE I/D genotypes were determined by polymerase chain reaction. Allelic frequencies and genotype distribution of the ACE I/D polymorphism in the patient group were significantly different from control subjects (ACE II genotype 29.6 vs. 17.6%, P = 0.011; ACE I allele 49.6 vs. 39.4%, P = 0.009). Our data suggest that the ACE I/D polymorphism could be a risk factor for patients with lung cancer.

• 出版日期2010-4-1