Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils

作者：Cheng Lin Yang; Liao Risiang Ruei; Chen Li Chai; Wang Shih Wei; Kuo Yueh Hsiung; Chung Mei Ing; Chen Jih Jung^*

来源：Fitoterapia, 2017, 117: 16-21.

DOI：10.1016/j.fitote.2016.12.008

• Pachira aquatica
• Bombacaceae
• Structure elucidation
• Naphthofuranone
• Anti-inflammatory activity

Two new naphthofuranone derivatives, 11-hydroxy-2-0-methylhibiscolactone A (1) and 0-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3-20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-0-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50 <= 28.84 mu M) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

• 出版日期2017-3
• 单位中国医科大学