科研之友
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摘要
Herein we demonstrate the utilization of neighboring ortho-hydroxy group participation in the pretransition state of enamine- and iminium-based triple domino reactions for high reactions rates and asymmetric induction. Enantiomerically pure, drug-like chromanes and tetrahydro-6H-benzo[c]chromenes having three to four contiguous stereocenters are synthesized through triple domino Michael/aldol/oxa-Michael reactions catalyzed by (R)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine followed by Wittig and Michael/Wittig-Horner reactions from simple precursors under mild conditions.
- 出版日期2014-5
