Association of the Common Catalase Gene Polymorphism rs1001179 With Glycated Hemoglobin and Plasma Lipids in Hyperlipidemic Patients

作者：Goulas Antonis^*; Agapakis Dimitrios; Apostolidis Athanassios; Gouda Dimitra; Anastassiadis Sotirios; Trakatelli Christina; Savopoulos Christos; Hatzitolios Apostolos I

来源：Biochemical Genetics, 2017, 55(1): 77-86.

DOI：10.1007/s10528-016-9777-2

• Catalase
• Gene polymorphism
• rs1001179
• Glycated hemoglobin
• Plasma lipids

Catalase represents perhaps the most effective antioxidant defense in the body under conditions of increased oxidative stress, and rs1001179 (CAT-262C>T) is its most extensively studied gene polymorphism. Using an established PCR-RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece. Our results suggest that the TT genotype is a risk factor for increased HbA1c and plasma triglycerides, and that this association is modulated by the BMI and/or age of the patients.

• 出版日期2017-2