Decreased fetal pre-adipocyte factor-1 in pregnancies complicated by gestational diabetes mellitus

作者：Li, Jie; Zhu, Qiuyuan; Wang, Hanzhi; Han, Cong; Zhou, Qunyan; Huang, Hefeng; Dong, Minyue^*

来源：Clinica Chimica Acta, 2014, 431: 93-95.

DOI：10.1016/j.cca.2014.01.048

• Gestational diabetes
• Preadipocyte factor-1
• Fetus
• Metabolic diseases

Background: Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood. We hypothesized that preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with gestational diabetes mellitus (GDM). @@@ Methods: Umbilical cord blood pref-1 concentrations were determined by enzyme-linked immunosorbant assay in 37 fetuses from pregnancies complicated by GDM and 45 fetuses from normal pregnancies. @@@ Results: Serum pref-1 concentrations were significantly lower in fetuses of women with GDM compared to normal pregnancies (16.12 +/- 6.48 vs. 22.09 +/- 7.22 mu g/l, P = 0.001). Birth weight was significantly higher in GDM fetuses compared to normal pregnancies (3567 +/- 544 vs. 3253 +/- 370 g, P = 0.003). @@@ Conclusions: Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies. These differences may be significant in terms of their later development of metabolic conditions.

• 出版日期2014-4-20
• 单位浙江大学