科研之友
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摘要
Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl) cyclododecane) complex from acetic to propionic accelerates the water exchange rate (k(ex)) by nearly two orders of magnitude; the H-1 relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems.
- 出版日期2009
