Association between serum uric acid and bone health in general population: a large and multicentre study

作者：Lin, Xianfeng; Zhao, Chenchen; Qin, An; Hong, Dun; Liu, Wenyue; Huang, Kangmao; Mo, Jian; Yu, Hejun; Wu, Shengjie; Fan, Shunwu^*

来源：Oncotarget, 2015, 6(34): 35395-35403.

DOI：10.18632/oncotarget.6173

• serum uric acid
• bone health
• bone mineral density
• bone mass loss
• DXA
• Gerotarget

Previous studies proposed that serum uric acid (UA), an endogenous antioxidant, could be a protective factor against bone loss. However, recently, a study with a population of US adults did not note the protective effects of serum UA. Therefore, the exact association between serum UA and bone health remains unclear. We performed a retrospective consecutive cohort study in a Chinese population to examine the association between serum UA and bone health. This cross-sectional study included 17,735 individuals who underwent lumbar spine bone mineral density (BMD) measurements as part of a health examination. In covariance analyses (multivariable-adjusted), a high serum UA level was associated with a high BMD, T-score, and Z-score. In binary logistic regression analyses (multivariable-adjusted), a high serum UA level was associated with low odds ratios (ORs) for at least osteopenia and osteoporosis in male (age >= 50 years) (OR = 0.72-0.60 and OR = 0.49-0.39, respectively) and postmenopausal female participants (OR = 0.61-0.51 and OR = 0.66-0.49, respectively). In conclusion, serum UA is associated with BMD, the T-score, and the Z-score, and has a strong protective effect against at least osteopenia and osteoporosis.

• 出版日期2015-11-3
• 单位上海交通大学; 浙江大学; 温州医科大学