Assessing the impact of FoxP3 and Vav1 gene polymorphisms on kidney allograft survival

作者：Adamek M; Doehler B; Hasan K K; Fiedler G; Scherer S; Opelz G; Tran T H^*

来源：HLA, 2017, 90(2): 102-105.

DOI：10.1111/tan.13049

• FoxP3
• gene polymorphism
• graft rejection
• kidney transplantation
• Vav1

FoxP3 and Vav1 are known to be involved in the development of regulatory T cells. Two polymorphic sites in the FoxP3 promoter (rs3761548 and a (GT)(n)-dinucleotide repeat) and 2 single nucleotide polymorphisms in intron 1 of the Vav1 gene (rs2546133 and rs2617822) have been shown to correlate with gene expression levels. We investigated a potential impact of FoxP3 and Vav1 genetic variants on kidney allograft failure using samples and data of the Collaborative Transplant Study. A cohort of 384 kidney transplant patients was tested. We found no significant association of FoxP3 promoter rs3761548 or (GT)(n) repeat length with presumed immunological graft failure. The genotype frequencies of Vav1 intron polymorphisms did not significantly differ between patients with graft failure and matched controls.

• 出版日期2017-8