Development of a New Method To Prepare Nano-/microparticles Loaded with Extracts of Azadirachta indica, Their Characterization and Use in Controlling Plutella xylostella

作者：Forim Moacir Rossi^*; Costa Eveline Soares; das Gracas Fernandes da Silva Maria Fatima; Fernandes Joao Batista; Mondego Janaina Marques; Boica Junior Arlindo Leal

来源：Journal of Agricultural and Food Chemistry, 2013, 61(38): 9131-9139.

DOI：10.1021/jf403187y

• Azadirachta indica
• nanoparticles
• spray-dried powders
• stability
• Plutella xylostella

Biodegradable nanoparticles have been widely explored as carriers for controlled delivery of therapeutic molecules; however, studies describing the development of nanoparticles as carriers for biopesticide products are few. In this work, a new method to prepare nanoparticles loaded with neem (Azadirachta indica) extracts is presented. In this study, nanoparticles were formulated as colloidal suspension and (spray-dried) powder and characterized by evaluating pH, particle size, zeta potential, morphology, absolute recovery, and entrapment efficiency. A high-performance liquid chromatography method was used for nanoparticle characterization. The best formulations presented absolute recovery and entrapment efficiencies of approximately 100% and a release profile based on swelling and relaxation of the polymer or polymer erosion. The biological data of the formulated products against Plutella xylostella showed 100% larval mortality. The nanoparticle information improved the stability of neem products against ultraviolet radiation and increased their dispersion in the aqueous phase.

• 出版日期2013-9-25