Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases

作者：Lee Sunyi; Han Sora; Jeong Ae Lee; Park Jeong Su; Yang Young^*

来源：FEBS LETTERS, 2014, 588(17): 2844-2850.

DOI：10.1016/j.febslet.2014.06.046

• Aurora A
• CDK1
• IK
• Mitotic arrest
• Protein phosphatase

IK is known to inhibit the expression of major histocompatibility complex (MHC) class II antigen, but other cellular functions of IK remain to be uncovered. In this study, IK depletion caused misalignment of chromosomes through an increase in Aurora A and PLK1 phosphorylation, which was mediated by a decrease in PP1 and PP2A activities. On the other hand, the treatment of a dual inhibitor against CDK and Aurora kinases overrode IK depletion-induced mitotic arrest through the activation of phosphatase activity. These findings imply that IK is an essential protein for achieving correct mitotic progress through the regulation of mitotic kinases and phosphatases.
Structured summary of protein interactions:
CIP2A physically interacts with IK by anti bait coip (View interaction)
Aurora A physically interacts with IK by anti tag coimmunoprecipit

• 出版日期2014-8-25