Analysis of EIF4G1 in Parkinson's disease among Asians

作者：Zhao Yi; Ho Patrick; Prakash Kumar M; Foo Jia Nee; Liu Jian Jun; Au Wing Lok; Tan Louis C; Tan Eng King^*

来源：Neurobiology of Aging, 2013, 34(4): 1311. e5.

DOI：10.1016/j.neurobiolaging.2012.09.003

• Parkinson's disease
• Gene

Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.

• 出版日期2013-4